OVEREXPRESSION OF P-GLYCOPROTEIN, MRP2, AND CYP3A4 IMPAIRS INTESTINAL ABSORPTION OF OCTREOTIDE IN RATS WITH PORTAL HYPERTENSION

Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension

Abstract Background Portal hypertension (PH) is the main cause of complications and death in liver cirrhosis.The effect of oral administration of octreotide (OCT), a drug that reduces PH by the constriction of mesenteric arteries, is limited by a remarkable intestinal first-pass elimination.Methods The bile duct ligation (BDL) was used in rats to i

read more

Prevalence of the Most Frequent Neuropsychiatric Diagnoses in Hospitalized SARS-CoV-2 Patients Evaluated by Liaison Psychiatry: Cross-Sectional Study

Introduction: The SARS-CoV-2 infection has been associated with the acute onset of mental and behavioural symptoms and psychiatric disorders.The aim of this study was to assess the prevalence of the different neuropsychiatric diagnoses in hospitalized patients with SARS-CoV-2 infection assessed by Liaison Psychiatry.Material and Methods: wella colo

read more