Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension
Abstract Background Portal hypertension (PH) is the main cause of complications and death in liver cirrhosis.The effect of oral administration of octreotide (OCT), a drug that reduces PH by the constriction of mesenteric arteries, is limited by a remarkable intestinal first-pass elimination.Methods The bile duct ligation (BDL) was used in rats to i